Toll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis.

Gut. 2009 Jun;58(6):771-6. doi: 10.1136/gut.2008.168443. Yersinia pseudotuberculosis causes ileitis and mesenteric lymphadenitis by mainly invading the Peyer’s patches that are Our data demonstrated that Tlr2-deficient mice failed to limit Yersinia dissemination from the Peyer’s patches and succumbed to sepsis independently of nucleotide-binding and oligomerisation domain 2 (NOD2). Recognition of both microbiota-derived and myeloid differentiation factor 88 En savoir plus surToll-like receptor 2 is critical for induction of Reg3 beta expression and intestinal clearance of Yersinia pseudotuberculosis.[…]