Interplay between troponin T phosphorylation and O-N-acetylglucosaminylation in ischaemic heart failure

Cardiovasc Res. 2015 Jul 1;107(1):56-65

Previous studies have reported that decreased serine 208 phosphorylation of troponin T (TnTpSer208) is associated with ischaemic heart failure (HF), but the molecular mechanisms and functional consequences of these changes are unknown. The aim of this study was to characterize the balance between serine phosphorylation and ON-acetylglucosaminylation (O-GlcNAcylation) of TnT in HF, its mechanisms, and the consequences of modulating these post-translational modifications.

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Quantifying bacterial adhesion on antifouling polymer brushes via single-cell force spectroscopy

Polym. Chem., 2015,6, 5740-5751

Bacterial adhesion poses serious problems in food safety and biomedical applications. Antifouling polymer brushes have been shown to be effective as surface modifications to prevent biofilm formation from pathogenic bacteria. In this work, the adhesion of Yersinia pseudotuberculosis on seven types of brushes is examined by single-cell force spectroscopy. The brushes, known to possess excellent resistance to protein adsorption, […]