MET amplification increases the metastatic spread of EGFR-mutated NSCLC

Published online: September 11, 2018 – DOI: https://doi.org/10.1016/j.lungcan.2018.09.008 Background Five to 20% of metastatic EGFR-mutated non-small cell lung cancers (NSCLC) develop acquired resistance to EGFR tyrosine kinase inhibitors (EGFR-TKI) through MET amplification. The effects of MET amplification on tumor and patient phenotype remain unknown. Methods We investigated,in vitro and in vivo, the impact of MET En savoir plus surMET amplification increases the metastatic spread of EGFR-mutated NSCLC[…]

MAGP-1 and fibronectin control EGFL7 functions by driving its deposition into distinct endothelial extracellular matrix locations

19 October 2018 – https://doi.org/10.1111/febs.14680 The extracellular matrix (ECM) is essential to provide mechanical support to tissues but is also a bioactive edifice which controls cell behavior. Cell signaling generated by ECM components through integrin-mediated contacts, modulates cell biological activity. In addition, by sequestrating or releasing growth factors, the ECM is an active player of physiological En savoir plus surMAGP-1 and fibronectin control EGFL7 functions by driving its deposition into distinct endothelial extracellular matrix locations[…]

Fifteen years of Servitude et Grandeur to the application of a biophysical technique in medicine: The tale of AFMBioMed

 18 December 2018 – https://doi.org/10.1002/jmr.2773 AFMBioMed is the founding name under which international conferences and summer schools are organized around the application of atomic force microscopy in life sciences and nanomedicine. From its inception at the Atomic Energy Commission in Marcoule near 2004 to its creation in 2007 and to its 10th anniversary conference in Krakow, En savoir plus surFifteen years of Servitude et Grandeur to the application of a biophysical technique in medicine: The tale of AFMBioMed[…]

The puzzling construction of the conidial outer layer of Aspergillus fumigatus

15 December 2018 – https://doi.org/10.1111/cmi.12994 If the mycelium of Aspergillus fumigatus is very short-lived in the laboratory, conidia can survive for years. This survival capacity and extreme resistance to environmental insults is a major biological characteristic of this fungal species. Moreover, conidia which easily reach the host alveola, are the infective propagules. Earlier studies have shown En savoir plus surThe puzzling construction of the conidial outer layer of Aspergillus fumigatus[…]

Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria.

Front. Microbiol., 24 September 2018 | https://doi.org/10.3389/fmicb.2018.02258 The heparin-binding hemagglutinin adhesin (HBHA) is an important virulence factor of Mycobacterium tuberculosis. It is a surface-displayed protein that serves as an adhesin for non-phagocytic cells and is involved in extra-pulmonary dissemination of the tubercle bacillus. It is also an important latency antigen useful for the diagnosis of En savoir plus surHeparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria.[…]