Cellular Microbiology and Physics of Infection

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The laboratory celebrates the 80th anniversary of the CNRS
Blocking bacterial entry at the adhesion step reveals dynamic recruitment of membrane and cytosolic probes
Stiffness tomography of eukaryotic intracellular compartments by atomic force microscopy
Transversal elasticity of TIEG1 KO muscle fibers probed by atomic force microscopy
Development of a novel multiphysical approach for the characterization of mechanical properties of musculotendinous tissues
Automated multi-sample acquisition and analysis using atomic force microscopy for biomedical applications
10 ans des Apprench’tis Chercheurs

10 ans des Apprench’tis Chercheurs

MET amplification increases the metastatic spread of EGFR-mutated NSCLC
MAGP-1 and fibronectin control EGFL7 functions by driving its deposition into distinct endothelial extracellular matrix locations
Fifteen years of Servitude et Grandeur to the application of a biophysical technique in medicine: The tale of AFMBioMed
The puzzling construction of the conidial outer layer of Aspergillus fumigatus
Heparin-Binding Hemagglutinin Adhesin (HBHA) Is Involved in Intracytosolic Lipid Inclusions Formation in Mycobacteria.
Our research is divided into two main areas, including technological developments and the use of different experimental systems to address several aspects involved in the early stages of infection
We develop an inter-disciplinary approach

Our working hypothesis suggests that the viscoelastic properties of biological membranes participate in the regulation of the implementation of cell signaling complexes in response to a stimulus. The stimulus we choose is the host-pathogenic interaction that has the advantage of exacerbating the cell response. The signaling pathway is the activation of autophagy in response to infection. The methodology we are deploying is based on a correlative approach between force spectroscopy and super-resolution photonic and electron microscopy.

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Lab members

Vincent DUPRES

Maître de Conférence – Université de Lille

Ghaffar MUHARRAM

Associate professor/chair of excellence – University Lille 2/INSERM
Study autophagy-associated cellular responses to norovirus infection in macrophages related to Crohn-like inflammation.

Elisabeth Werkmeister

Ingénieure de Recherche – CNRS
Microscopie photonique de super-résolution et analyse d’images.

Sébastien JANEL

Ingénieur de Recherche – CNRS
Microscopie à force atomique

Fabio Perissinotto

Post-Doc – INSERM
Assembly and release of SNAREpins in the membrane for synaptic transmission

Joelle Warein

Technicienne – Institut Pasteur de Lille
Responsable de la culture cellulaire

Maria Luisa Marini

PhD Marie Skłodowska-Curie Innovative Training Networks
Nano-mechanics response measurements of cells and tissues in cancer

Javier López Alonso

PhD Marie Skłodowska-Curie Innovative Training Networks
Towards automation for nano-mechanics characterization of biological samples in diseases

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Our networks

GDR: Microscopie et imagerie du vivant - Physique de la cellule au tissus - Cosm’actif

Eu cost: afm4nanomed&bio - transautophagy - moebieu

Eu itn (H2020 marie-curie prgm): phys2biomeb

Réseaux technologiques: remisol - rtmfm - rccm

Société savantes: sbcf - cfatg - SFB-GEM

Elmi

FSL