J Cell Sci jcs.259119. | 08 DECEMBER 2021 Metabolic studies and animal knockout models point to the critical role of polyunsaturated docosahexaenoic acid (22:6, DHA)-containing phospholipids (PLs) in physiology. Here, we investigated the impact of DHA-PLs on the dynamics of transendothelial cell macroapertures (TEMs) triggered by RhoA inhibition-associated cell spreading. Lipidomic analyses show that human En savoir plus surDHA-phospholipids control membrane fusion and transcellular tunnel dynamics[…]