Cellular Microbiology and Physics of Infection

Our working hypothesis suggests that the viscoelastic properties of biological membranes participate in the regulation of the implementation of cell signaling complexes in response to a stimulus. The stimulus we choose is the host-pathogenic interaction that has the advantage of exacerbating the cell response. The signaling pathway is the activation of autophagy in response to infection. The methodology we are deploying is based on a correlative approach between force spectroscopy and super-resolution photonic and electron microscopy.