Autophagosomes can support Yersinia pseudotuberculosis replication in macrophages.

Cell Microbiol. 2010 Aug;12(8):1108-23. doi: 10.1111/j.1462-5822.2010.01456.x

Yersinia pseudotuberculosis is able to replicate inside macrophages. However, the intracellular trafficking of the pathogen after its entry into the macrophage remains poorly understood. Using in vitro infected bone marrow-derived macrophages, we show that Y. pseudotuberculosis activates the autophagy pathway. Host cell autophagosomes subverted by bacteria do not become acidified and sustain bacteria replication. Moreover, we report that autophagy inhibition correlated with bacterial trafficking inside an acidic compartment. This study indicates that Y. pseudotuberculosis hijacks the autophagy pathway for its replication  […]

Galectin-3, a marker for vacuole lysis by invasive pathogens.

Cell Microbiol. 2010 Apr 1;12(4):530-44. doi: 10.1111/j.1462-5822.2009.01415.x Shigella bacteria invade macrophages and epithelial cells and following internalization lyse the phagosome and escape to the cytoplasm. Galectin-3, an abundant protein in macrophages and epithelial cells, belongs to a family of beta-galactoside-binding proteins, the galectins, with many proposed functions in immune response, development, differentiation, cancer and infection. Galectins Read more about Galectin-3, a marker for vacuole lysis by invasive pathogens.[…]