2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations

Published: 20 March 2020 https://doi.org/10.1038/s41467-020-15140-z Nonsense mutations cause about 10% of genetic disease cases, and no treatments are available. Nonsense mutations can be corrected by molecules with nonsense mutation readthrough activity. An extract of the mushroom Lepista inversa has recently shown high-efficiency correction of UGA and UAA nonsense mutations. One active constituent of this extract Read more about 2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations[…]

Rab11A regulates dense granule transport and secretion during Toxoplasma gondii invasion of host cells and parasite replication

Published: May 28, 2020 https://doi.org/10.1371/journal.ppat.1008106 Toxoplasma gondii possesses an armada of secreted virulent factors that enable parasite invasion and survival into host cells. These factors are contained in specific secretory organelles, the rhoptries, micronemes and dense granules that release their content upon host cell recognition. Dense granules are secreted in a constitutive manner during parasite Read more about Rab11A regulates dense granule transport and secretion during Toxoplasma gondii invasion of host cells and parasite replication[…]

Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface

Published: 12 May 2020 https://doi.org/10.1038/s41419-020-2556-3 Cellular stress response contributes to epithelial defense in adaptation to environment changes. Galectins play a pivotal role in the regulation of this response in malignant cells. However, precise underlying mechanisms are largely unknown. Here we demonstrate that Galectin-3, a pro and anti-apoptotic lectin, is required for setting up a correct Read more about Galectin-3 modulates epithelial cell adaptation to stress at the ER-mitochondria interface[…]