2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations
Published: 20 March 2020 https://doi.org/10.1038/s41467-020-15140-z Nonsense mutations cause about 10% of genetic disease cases, and no treatments are available. Nonsense mutations can be corrected by molecules with nonsense mutation readthrough activity. An extract of the mushroom Lepista inversa has recently shown high-efficiency correction of UGA and UAA nonsense mutations. One active constituent of this extract Read more about 2,6-Diaminopurine as a highly potent corrector of UGA nonsense mutations[…]