Interplay between troponin T phosphorylation and O-N-acetylglucosaminylation in ischaemic heart failure

Cardiovasc Res. 2015 Jul 1;107(1):56-65

Previous studies have reported that decreased serine 208 phosphorylation of troponin T (TnTpSer208) is associated with ischaemic heart failure (HF), but the molecular mechanisms and functional consequences of these changes are unknown. The aim of this study was to characterize the balance between serine phosphorylation and ON-acetylglucosaminylation (O-GlcNAcylation) of TnT in HF, its mechanisms, and the consequences of modulating these post-translational modifications.